In October of 1904, Aaron Brown and eight of his friends founded Phi Delta Epsilon at Cornell University Medical College. During the first decade of this century there were many doors closed to Jewish medical students and physicians, doors which would not fully open until after World War II. In 1904, it was not uncommon for American medical schools to have quotas limiting admission of Jewish students, and medical fraternities. So Aaron Brown and his friends decided they would start their own fraternal organization, guided by the precepts of philanthropy, deity, and equity.

The success of the Cornell chapter soon led to the organization of other chapters in the East and Midwest. In 1918, Phi Delta Epsilon amalgamated with Alpha Phi Sigma, a medical fraternity organized in 1908, whose ideals and principles were similar to those of PhiDE. Its chapters were in the Midwest and West, making for an ideal union.

In the late 1960s, the Fraternity opened its membership to women and encouraged recruitment of medical students of all races, nationalities and religious beliefs. The past 25 years have seen the Fraternity's membership become wonderfully diverse, reflecting the diversity of the medical profession today. The addition of the premedical affiliation in 1994 rounded out the Fraternity's membership, which now spans an entire lifetime of medical education and practice.

PhiDE celebrated its 100th anniversary in 2004 as a strong, vibrant, professionally directed organization headed for new growth and great excitement. The 21st century beckons us, and we continue operate under Aaron Brown's guiding principles of Philanthropy, Deity, and Equity as largest premedical fraternity in the world. 

Our members are involved in a variety of organizations and extracurricular activities on campus and off. They hold leadership positions, from high to low, both professionally, personally, and academically. We are involved in a wide range of activities, anything from tutoring, research groups, volunteering, scribing, to basketball, baking, hiking, painting, and much more. We strive for excellence in everything we do.